Evidence map›Paper›PMID 41552269›Full record

ArticleTransactions on machine learning research2025

Knockout: A simple way to handle missing inputs.

Minh Nguyen, Batuhan K Karaman, Heejong Kim, Alan Q Wang, Fengbei Liu, Mert R Sabuncu

Abstract read
In one paragraph

Article in Transactions on machine learning research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minh NguyenCornell University.
Batuhan K KaramanCornell University.
Heejong KimWeill Cornell Medicine.
Alan Q WangCornell University.
Fengbei LiuCornell University.
Mert R SabuncuCornell University and Weill Cornell Medicine.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Deep Learning Algorithms for FreeSurferR01AG064027 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2020 to 2024
$3.4M
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7M
Advanced machine learning algorithms that integrate genomewide, longitudinal MRI and demographic data to predict future cognitive decline toward dementiaR01AG053949 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SABUNCU, MERT RORY · 2017 to 2021
$2.4M
Robust and Interpretable Multimodal Machine Learning Models for Diagnosis and Prognosis of Prostate CancerK25CA283145 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Heejong Kim · 2024 to 2026
$463k
NCI NIH HHS K25 CA283145NIA NIH HHS R01 AG053949NIA NIH HHS R01 AG064027NIA NIH HHS R01 AG070988NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Deep learning models benefit from rich (e.g., multi-modal) input features. However, multimodal models might be challenging to deploy, because some inputs may be missing at inference. Current popular solutions include marginalization, imputation, and training multiple models. Marginalization achieves calibrated predictions, but it is computationally expensive and only feasible for low dimensional inputs. Imputation may result in inaccurate predictions, particularly when high-dimensional data, such as images, are missing. Training multiple models, where each model is designed to handle different subsets of inputs, can work well but requires prior knowledge of missing input patterns. Furthermore, training and retaining multiple models can be costly. We propose an efficient method to learn both the conditional distribution using full inputs and the marginal distributions. Our method, Knockout, randomly replaces input features with appropriate placeholder values during training. We provide a theoretical justification for Knockout and show that it can be interpreted as an implicit marginalization strategy. We evaluate Knockout across a wide range of simulations and real-world datasets and show that it offers strong empirical performance.

Identifiers

PMID41552269
PMCPMC12809338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.