ArticleCureus2025
The Impact of Adjunct Hyperbaric Oxygen Therapy on Healing Diabetic Foot Ulcers: A Retrospective Case-Control Study at a Tertiary Care Center.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundA reduced oxygen supply to diabetic foot ulcers slows down wound healing, as it affects angiogenesis, reepithelialization, and extracellular matrix formation. A compromised blood supply impairs oxygen delivery to the wound, creating a hypoxic environment around it. Hyperbaric oxygen therapy (HBOT) increases the concentration of dissolved oxygen in the plasma. It compensates for the existing hypoxia and promotes wound healing. HBOT promotes neovascularization and matrix formation, decreases inflammation, and increases reactive oxygen free radicals, which can kill bacteria. Moreover, HBOT overwhelms the enzymes that reduce free radical production. Adverse effects are very rare when patients are carefully screened before treatment. However, HBOT cannot maintain the increased oxygen concentration. Therefore, a discussion of the overall benefits of HBOT for wound healing is warranted. This study aimed to evaluate the effect of HBOT on the healing of diabetic foot ulcers in terms of the time taken for complete wound healing.
methodsA retrospective case-control study was conducted at a tertiary care center on 235 inpatients selected according to defined inclusion and exclusion criteria. The patients' clinical parameters influencing wound healing, such as age, HbA
resultsLogistic regression showed that the HBOT group patients had improved wound healing (odds ratio (OR) = 2.84) compared with the control group patients. The logistic regression analysis indicated that the HBOT group was associated with a significant improvement in wound healing after accounting for the severity of diabetic foot ulcers. HBOT was predominantly used for patients with worse baseline ulcers, and the median time to healing was significantly longer in the HBOT group than in the control group. Potential confounders of the association between HBOT and wound healing were identified using a Bayesian network. Even after adjusting for potential confounders, HBOT showed a favorable trend (OR = 2.32), although it did not reach statistical significance.
conclusionThis study demonstrates a positive correlation between HBOT and the healing of diabetic foot ulcers. HBOT, when used as an adjunct to standard-of-care treatment, significantly shortened the time to healing in University of Texas grade 1 ulcers. Further research in this area may justify considering HBOT as a standard-of-care treatment for diabetic foot ulcers.
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