Clear Cell Myoepithelial Carcinoma of the Clavicle: A Case Report.

Clear cell myoepithelial carcinoma involving the clavicle is an exceptionally rare malignancy. Its nonspecific clinical and radiologic features pose significant diagnostic challenges, often mimicking more common primary bone tumors such as chondrosarcoma and osteosarcoma. We report the case of a 53-year-old male with a slowly enlarging, painless supraclavicular mass present for nearly a decade. Imaging studies suggested chondrosarcoma, and an initial fine-needle biopsy yielded a diagnosis of grade II chondrosarcoma. Staging showed no metastatic disease, and the patient underwent en bloc resection of the tumor with the affected clavicular segment, followed by reconstruction using a fibular autograft fixed with dual plating. Final histopathology and a comprehensive immunohistochemical panel confirmed the diagnosis of clear cell myoepithelial carcinoma. All margins were negative, and postoperative recovery was uneventful. This case highlights the diagnostic complexity of rare clavicular tumors and underscores the importance of thorough histopathologic evaluation, as imaging and needle biopsy may occasionally provide misleading diagnoses in uncommon bone lesions. Wide surgical excision remains the cornerstone of treatment, and reconstruction should be individualized based on defect size and regional anatomical considerations. Continued reporting of such rare cases is essential to improve diagnostic accuracy and guide treatment strategies.