ArticleCureus2025
Beyond Hypertrophy: A Case of Mid-ventricular Obstructive Hypertrophic Cardiomyopathy With Apical Sequestration.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apical sequestration is an often overlooked manifestation of mid-ventricular obstructive hypertrophic cardiomyopathy (MVO-HCM), in which dynamic mid-ventricular obstruction creates an anatomically and functionally isolated apical chamber with impaired distal perfusion. We describe a patient with MVO-HCM who developed apical sequestration complicated by flow stagnation, ischemic injury, and a small mural apical thrombus. Transthoracic echocardiography showed marked mid-ventricular hypertrophy with systolic narrowing. At the same time, cardiac magnetic resonance provided a more comprehensive characterization by demonstrating a mechanically trapped apical chamber, mid-ventricular intramural fibrosis, a small apical thrombus, and transmural late gadolinium enhancement consistent with ischemic injury. Coronary angiography revealed no obstructive disease, supporting a mechanism of obstruction-related flow limitation rather than epicardial coronary pathology. This case underscores apical sequestration as a high-risk morphological and physiological variant of MVO-HCM. It highlights the value of multimodality imaging, particularly cardiac magnetic resonance, in identifying this uncommon presentation and guiding clinical management.
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