Evidence map›Paper›PMID 41552023›Full record

ArticleInternational journal of clinical pediatric dentistry2025

Evaluation of AQP5 in Hypomineralized Teeth in Comparison to Normal Teeth: A Cross-sectional Study.

Sindhu Subramani, Ramya Sekar, Kavitha Bottu, Sabarinath Balaraman

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In one paragraph

Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Sindhu SubramaniDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College & Hospital, Meenakshi Academy of Higher Education & Research (Deemed to be University), Chennai, Tamil Nadu, India.ORCID https://orcid.org/0009-0005-2550-6408
Ramya SekarDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College & Hospital, Meenakshi Academy of Higher Education & Research (Deemed to be University), Chennai, Tamil Nadu, India.ORCID https://orcid.org/0000-0003-0381-2859
Kavitha BottuDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College & Hospital, Meenakshi Academy of Higher Education & Research (Deemed to be University), Chennai, Tamil Nadu, India.
Sabarinath BalaramanDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College & Hospital, Meenakshi Academy of Higher Education & Research (Deemed to be University), Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To quantitatively evaluate aquaporin 5 (AQP5) levels in the saliva of children with molar incisor hypomineralization (MIH) and compare them with those having normally mineralized teeth with dental caries and normally mineralized teeth. Also, to check the role of socioeconomic status (SES) in the incidence pattern. Methodology: A total of 75 children aged 6-12 years from Chennai, India, were divided equally into three groups: MIH, normally mineralized teeth with dental caries, and normally mineralized teeth. Saliva samples were collected using the passive pooling and analyzed for AQP5 levels using the enzyme-linked immunosorbent assay (ELISA) technique. Data were recorded and analyzed with SPSS software. Results: Aquaporin 5 levels in children with MIH were (0.808 ± 0.997 ng/mL), followed by those with normally mineralized teeth with dental caries (1.252 ± 0.2468 ng/mL) and normally mineralized teeth without dental caries (2.056 ± 0.3489 ng/mL). On intergroup comparison among groups A and B, A and C, and B and C were statistically significant ( Conclusion: Molar incisor hypomineralization and dental caries are multifactorial conditions impacting children's oral health. Future research should explore how crystallization of the enamel matrix affects them. Gene polymorphisms of AQP5, along with other genes, should be assessed to improve diagnostic approaches. How to cite this article: Subramani S, Sekar R, Bottu K,

Indexed as

Dental cariesDevelopmental defects of enamelFirst permanent molarMolar incisor hypomineralizationSocioeconomic status

Identifiers

PMID41552023
PMCPMC12810163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.