ArticleInternational journal of clinical pediatric dentistry2025
Quantification and Correlation of Salivary Tissue Inhibitor Matrix Metalloproteinases 1 and 2 Levels in Caries-free and Caries-active Children: A Randomized Clinical Trial.
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- AQP3 as a potential biomarker for caries.BMC oral health · 2026Observational
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2 authors.
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Abstract
Objectives: Extracellular matrix (ECM) proteolysis is carried out by a class of enzymes called matrix metalloproteases (MMPs). Tissue inhibitors of metalloproteinases (TIMPs), which have a broad binding range for various enzyme types, control MMPs. The purpose of this study is to quantify and correlate salivary TIMP-1 and 2 levels in children who are caries-active and caries-free. Materials and methods: A total of 40 children, aged 3-6, were split into two groups for the study: 20 in each group (caries-active and caries-free). Saliva samples that had not been stimulated were collected and analyzed using enzyme-linked immunosorbent assay (ELISA). Age, gender, and caries score will all be taken into consideration when estimating and correlating TIMP-1 and 2 levels. Results: TIMP-1 levels were statistically significant at Conclusion: In comparison to those who are caries-active, it demonstrated a correlation with elevated levels of TIMP-1, indicating a protective function of this protein against dental caries. TIMP-1 may have a role in preserving dental health and preventing the progression of caries. Therefore, TIMP-1 detection can be considered as a molecular biomarker for early childhood caries (ECC) diagnosis. How to cite this article: Thimmegowda U, Sampreetha G. Quantification and Correlation of Salivary Tissue Inhibitor Matrix Metalloproteinases 1 and 2 Levels in Caries-free and Caries-active Children: A Randomized Clinical Trial. Int J Clin Pediatr Dent 2025;18(12):1461-1465.
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