Evidence map›Paper›PMID 41552012›Full record

ArticleFrontiers in cell and developmental biology2025

Preclinical biodistribution and safety evaluation of human iPSC-derived dopaminergic neural progenitor cells for Parkinson's disease.

Ying Huang, Hairuo Wen, Lily Li, Lulu Li, Qianqian Li, Chao Qin, Yiyang Mao, Zhi Lin, Hua Jiang, Frank Zhu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ying Huang *Institute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Hairuo Wen *Institute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Lily LiXellSmart Biopharmaceutical (Suzhou) Co., Ltd, Suzhou, China.
Lulu LiInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Qianqian LiInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Chao QinInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Yiyang MaoInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Zhi LinInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Hua JiangInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.
Frank ZhuXellSmart Biopharmaceutical (Suzhou) Co., Ltd, Suzhou, China.
Xiang LiXellSmart Biopharmaceutical (Suzhou) Co., Ltd, Suzhou, China.
Xingchao GengInstitute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Human pluripotent stem cells (PSCs) have the potential to revolutionize regenerative medicine, but their clinical safety has not been thoroughly investigated. We investigated the Methods: For the biodistribution study, DAPs were injected into the unilateral striatum of NSG mice, and the distribution and differentiation of the transplanted cells were determined via immunofluorescence staining and qPCR at 1-, 28-, 84-, and 168-days post-administration. The toxicity and tumorigenicity studies were carried out on NSG mice by administering saline, 1 × 10 Results: Brain-only discovery of DAP markers (Ki67, FOXA2, OTX2, STEM101, and STEM121) and specific sequences of DAPs was confirmed. From 1- to 184-days, the copy number of Discussion: This study developed a novel method for determining biodistribution and differentiation

Indexed as

biodistributionhuman iPSC-derived dopaminergic neural progenitor cellsin vivo differentiationParkinson’s diseasesafety evaluation study

Identifiers

PMID41552012
PMCPMC12808374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.