Evidence map›Paper›PMID 41551982›Full record

ArticleInternational journal of pharmaceutics: X2026

Gold-incorporated hyaluronic acid nanoparticles enhance ablative radiotherapy efficacy in lung cancer.

Jenny Ling-Yu Chen, Shu-Jyuan Yang, Li-Cheng Lin, Chun-Kai Pan, Ching-Yi Tsai, Yu-Sen Huang, Ke-Cheng Chen, Ming-Jium Shieh, Yu-Li Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenny Ling-Yu ChenDepartment of Radiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Shu-Jyuan YangInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Li-Cheng LinDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Chun-Kai PanDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Ching-Yi TsaiDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Yu-Sen HuangDepartment of Radiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Ke-Cheng ChenDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Jium ShiehInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Yu-Li LinDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the utility of Au-incorporated hyaluronic acid nanoparticles (Au/HA NPs) for improving the therapeutic efficacy of ablative radiotherapy (RT) for tumor control and microenvironment remodeling. HA-functionalized NPs exhibited uniform size, stability, and efficient SN38 encapsulation. Au incorporation increased NP diameter and reduced surface charge while remaining stable. HA and Au/HA NPs were efficiently internalized by lung cancer cells, with free HA pretreatment suppressing internalization. Moreover, Au/HA NP internalization strongly downregulated CD44 expression in lung cancer cells, confirming CD44-mediated internalization.

Indexed as

Ablative radiotherapyAntitumor immunityGold nanoparticlesImmunogenic cell deathLung cancer

Identifiers

PMID41551982
PMCPMC12808585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.