Evidence map›Paper›PMID 41551933›Full record

ArticleStem cells international2026

Intracavernous Injection of Mechanically Extracted Stromal Vascular Fragments Suppresses Endothelial-Mesenchymal Transformation to Mitigate Erectile Dysfunction in Hypertensive Rats.

Cheng Shao, Yi Sun, Jun Zhao, Chao Ju, Tianli Yang, Jingyu Liu, Liuhua Zhou, Ruipeng Jia, Feng Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng ShaoDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Yi SunDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Jun ZhaoDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Chao JuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Tianli YangDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Jingyu LiuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Liuhua ZhouDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Ruipeng JiaDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.ORCID https://orcid.org/0000-0002-5532-5641
Feng ZhaoDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.ORCID https://orcid.org/0000-0001-7111-4812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erectile dysfunction (ED) is widespread among individuals with high blood pressure and negatively affects quality of life. The effect of stromal vascular fraction (SVF) on hypertension-related ED remains unexplored. We used a hypertensive rat model to explore the relative efficacy of adipose tissue stromal vascular fraction (tSVF) and cellular SVF (cSVF). We then investigated the possible mechanisms of these treatments. Hypertensive rats were divided into three groups according to different treatments. Their intracavernous pressure (ICP) during erection and condition of cavernous tissue were compared to those of the controlled group. Endothelial-mesenchymal transformation (EndMT) markers as well as related inflammatory factors were also measured. cSVF and tSVF were labeled with CM-Dil before injection in order to determine whether cSVF and tSVF survived, proliferated, and transdifferentiated in vivo. The increased ICP during erection demonstrated that tSVF treatment significantly improved hypertension-related ED. tSVF increased the smooth muscle-to-collagen ratio and inhibiting the expression of fibrosis-related proteins in hypertensive rats while rescuing the expression of vWF and eNOS, which indicated the preserving of endothelial tissue of the penis. Immunofluorescence staining and western blotting of penile tissue clearly suggest the inhibitory effect of tSVF on the overoccurring EndMT. Immunofluorescence staining and Western blot analysis of endothelial cells in vitro corroborate the whole-tissue findings. The experiments in N-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced human umbilical vein endothelial cells (HUVECs) revealed tSVF suppresses EndMT via inhibiting the TGF-

Indexed as

cellular stromal vascular fractionendothelial-mesenchymal transformationerectile dysfunctionhypertensionstem celltissue adipose stromal vascular fraction

Identifiers

PMID41551933
PMCPMC12809916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.