ArticleLancet regional health. Americas2026
Intensity-modulated proton therapy vs intensity-modulated radiotherapy in nasopharyngeal carcinoma: a case-control study.
Article in Lancet regional health. Americas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis.Frontiers in surgery · 2026Pooled it
- Endodontic Management Before, During and After Head and Neck Radiotherapy: Biological, Diagnostic and Clinical Considerations in Head and Neck Cancer Patients.International endodontic journal · 2026Review
- Prognostic value of pre- and post-treatment neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios in nasopharyngeal carcinoma.Molecular and clinical oncology · 2026Article
- Illumination of Targeting Nanotherapeutics with Precision Eyes: From Optical to Radio-nanotheranostics.Theranostics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Background: Intensity-modulated proton therapy (IMPT) is associated with fewer acute toxicities compared with intensity-modulated radiotherapy (IMRT) in definitive treatment of nonmetastatic nasopharyngeal carcinoma (NPC). Longer term efficacy and safety data are warranted to appraise the comparative benefit of IMPT for this population. The aim of this study was to evaluate the long-term toxicity and survival outcomes of NPC treated with IMPT vs IMRT at a tertiary academic cancer center during 2016-2022. Methods: Sixty-seven (42.1%) cases treated by IMPT, and 92 (57.9%) controls treated by IMRT were included. Findings: The median follow-up time was 55.4 months (interquartile range [IQR], 32.1-73.8 months). The incidence of any grade 2+ acute toxicity was lower with IMPT than IMRT (86.6% vs 97.8%, p = 0.009). Based on the logistic regression analysis, radiotherapy modality (IMRT vs IMPT) was significantly associated with developing any grade 2+ acute toxicity (odds ratio, 0.177; 95% confidence interval 0.035-0.886; p = 0.035). The incidence of grade 2+ late toxicity was not significantly different (p > 0.05) following IMPT (40.3%) and IMRT (52.7%). There were no statistically significant differences following IMRT and IMPT in 5-year cumulative incidence of local or regional failures [16.4% (9.1-25.6) vs 14.1% (6.5-24.7)], progression free survival and overall survival. Interpretation: Although there were no statistically significant differences in incidence of late toxicities or oncologic outcomes, IMPT was associated with lower incidence of acute toxicity in comparison with IMRT. Funding: This research was funded in part through the National Institutes of Health/National Cancer Institute Cancer Center Support Grant P30 CA008748.
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