Evidence map›Paper›PMID 41551912›Full record

ArticleResearch (Washington, D.C.)2026

Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1α in Granulosa Cells.

Gang Wu, Min Chen, Chengyu Li, Mengli Wei, Yitong Pan, Tong He, Zhaojun Liu, Hongmin Li, Chunlei Zhang, Jia-Qing Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. mRedox biology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gang WuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID https://orcid.org/0009-0002-5503-1384
Min ChenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Chengyu LiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Mengli WeiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yitong PanCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Tong HeCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Zhaojun LiuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Hongmin LiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Chunlei ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Jia-Qing ZhangInstitute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Yanan ShengCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yang LiuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Honglin LiuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Ming ShenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic flux coupled to mitochondrial biogenesis remains unclear. Here, we demonstrate that histone lactylation functions as a lactate-sensitive epigenetic mediator linking FSH-driven metabolic alterations to mitochondrial biogenesis in GCs. Mechanistically, FSH increases intracellular lactate levels through glycolytic activation, thereby promoting P300/CBP-dependent lactylation of histone H4 at lysine 5 (H4K5la). H4K5la directly enhances HDAC4 expression, and HDAC4 subsequently deacetylates PGC-1α at lysine residues 329/330. Deacetylated PGC-1α cooperates with nuclear respiratory factors NRF1/2 to drive transcription of key mitochondrial regulators (

Identifiers

PMID41551912
PMCPMC12804605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.