Continuous positive airway pressure on left ventricular ejection fraction in obstructive sleep apnea and heart failure with reduced ejection fraction: a systematic review and meta-analysis.

Chou-Han Lin, Yen-Wen Wu, Chih-Chieh Yu

Abstract read

In one paragraph

Article in Sleep and biological rhythms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chou-Han LinDivision of Respiratory Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Yen-Wen WuDivision of Cardiology, Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Chih-Chieh YuDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung San South Road, Taipei City, 100 Taiwan.ORCID 0000-0002-2136-2444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous positive airway pressure (CPAP) is the primary treatment for obstructive sleep apnea (OSA), with fixed pressure CPAP (FP-CPAP) and auto-titrating CPAP (Auto-CPAP) being the two modes. We examined the impact of CPAP on left ventricular ejection fraction (LVEF) in patients with OSA and heart failure with reduced ejection fraction (HFrEF). A meta-analysis of 10 randomized control trials (233 CPAP users, 242 controls) was conducted. LVEF was the primary outcome. CPAP significantly increased LVEF (mean difference: 3.72, 95% CI 2.21-5.23). FP-CPAP improved LVEF (4.84, 95% CI 3.23-6.45), while Auto-CPAP showed no significant effect. The cardiovascular benefits of CPAP in patients with OSA and HFrEF may vary by mode, suggesting a potential mode-specific effect between FP-CPAP and Auto-CPAP that warrants further investigation

Indexed as

Continuous positive airway pressureHeart failureLeft ventricular ejection fractionObstructive sleep apnea

Identifiers

PMID41551897

DOI10.1007/s41105-025-00604-w

PMCPMC12804498

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.