Evidence map›Paper›PMID 41551851›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Factors associated with discordant visual and quantitative amyloid PET results.

Jasmin E Guevara, Emily F Matusz, Wei-En Wang, Jesse C DeSimone, Batul Yawer, Jacob Fiala, Shellie-Anne Levy, Franchesca Arias, Sruti Rayaprolu, Warren W Barker and 11 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jasmin E GuevaraDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.ORCID https://orcid.org/0000-0002-3621-8306
Emily F MatuszDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Wei-En Wang1Florida ADRC Gainesville Florida USA.
Jesse C DeSimone1Florida ADRC Gainesville Florida USA.
Batul YawerDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Jacob FialaDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Shellie-Anne LevyDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Franchesca AriasDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Sruti Rayaprolu1Florida ADRC Gainesville Florida USA.
Warren W Barker1Florida ADRC Gainesville Florida USA.
Michael M MarsiskeDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Rosie E Curiel Cid1Florida ADRC Gainesville Florida USA.
Steven T DeKosky1Florida ADRC Gainesville Florida USA.
Nikolaus R McFarland1Florida ADRC Gainesville Florida USA.
Melissa J Armstrong1Florida ADRC Gainesville Florida USA.
Malek Adjouadi1Florida ADRC Gainesville Florida USA.
David E Vaillancourt1Florida ADRC Gainesville Florida USA.
Glenn E SmithDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
David A Loewenstein1Florida ADRC Gainesville Florida USA.
Ranjan Duara1Florida ADRC Gainesville Florida USA.
Breton M AskenDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.

Funding

Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Ranjan Duara, DAVID LOEWENSTEIN · 2020 to 2026
$25.6M
Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
NIA NIH HHS P30 AG066506NIH HHS S10 OD021726
6 · The paper itself

Abstract

introductionFactors underlying discordant visual and quantitative amyloid beta-positron emission tomography (Aβ-PET) results and their clinical implications are not well understood.

methodsParticipants from the 1Florida Alzheimer's Disease Research Center (1FLADRC) underwent Aβ-PET, blood draw, brain magnetic resonance imaging (MRI), and neuropsychological testing. We evaluated differences in demographics, apolipoprotein E (

resultsWe studied 386 participants (mean age ± SD: 70.7 ± 7.8, 55.2% female, 44.6% Hispanic White). Compared to V+/Q-, V-/Q+ had a higher frequency of DISCUSSION: Discordant Aβ-PET findings likely hold clinical significance and may reflect early stages of neuropathological progression. Highlights: Groups with concordant/discordant visual-quantitative amyloid beta-positron emission tomography (Aβ-PET) results were compared.Visual-/quant+ were more likely than visual+/quant- to be apolipoprotein E (

Indexed as

Alzheimer's diseaseamyloid PETCentiloidcognitionplasma biomarkers

Identifiers

PMID41551851
PMCPMC12805418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.