ArticleGastro hep advances2026
Increasing Social Vulnerability Impacts Presentation and Decreases Treatment Response in Eosinophilic Esophagitis.
Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Diffuse esophageal eosinophilia is associated with increased endoscopic severity and topical steroid non-response in patients with eosinophilic esophagitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
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Authors and funding
18 authors.
Funding
Abstract
Background and Aims: Social vulnerability describes relative disadvantage according to demographics, socioeconomic status, and resources. The impact of social vulnerability on eosinophilic esophagitis (EoE) remains unknown. We aimed to determine whether social vulnerability influences EoE presentation or treatment outcomes. Methods: We conducted a retrospective cohort study of patients of any age with newly diagnosed EoE. The social vulnerability index (SVI) was used to estimate patients' relative vulnerability (with higher scores indicating more vulnerability). For patients with topical corticosteroid (tCS) treatment or dietary elimination and a follow-up endoscopy, we assessed histologic, symptomatic, and endoscopic responses. We compared baseline characteristics and post-treatment responses by SVI. Results: Among 1457 patients, the mean SVI was 0.42 ± 0.26. Patients with higher SVIs frequently presented with atypical symptoms like vomiting ( Conclusion: In patients with EoE, higher social vulnerability was independently associated with lower histologic response to tCS. This association warrants further exploration of explanatory factors, including treatment adherence and increased allostatic load.
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