Evidence map›Paper›PMID 41551608›Full record

ArticleExtracellular vesicles and circulating nucleic acids2025

Preanalytical framework for routine clinical use of liquid biopsies: combining EVs and cfDNA.

Nike K Simon, Stefanie Volz, Jussara Rios de Los Rios Reséndiz, Tatjana Wedig, Sophia H Montigel, Nathalie Schwarz, Karsten Richter, Dominic Helm, Michelle Neßling, Lin Zielske and 8 more

Abstract read
In one paragraph

Article in Extracellular vesicles and circulating nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nike K SimonDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Stefanie VolzDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Jussara Rios de Los Rios ReséndizJunior Clinical Cooperation Unit Translational Lymphoma Research, German Cancer Research Center (DKFZ) Heidelberg, Mannheim 68169, Germany.
Tatjana WedigDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Sophia H MontigelDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Nathalie SchwarzDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Karsten RichterCore Facility Electron Microscopy, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Dominic HelmProteomics Core Facility, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Michelle NeßlingCore Facility Electron Microscopy, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Lin ZielskeJunior Clinical Cooperation Unit Translational Lymphoma Research, German Cancer Research Center (DKFZ) Heidelberg, Mannheim 68169, Germany.
Julia BerkerJunior Clinical Cooperation Unit Translational Lymphoma Research, German Cancer Research Center (DKFZ) Heidelberg, Mannheim 68169, Germany.
Sophia RusseckJunior Clinical Cooperation Unit Translational Lymphoma Research, German Cancer Research Center (DKFZ) Heidelberg, Mannheim 68169, Germany.
Monika MauermannDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Wolf-Karsten HofmannDepartment of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
Stefan M PfisterDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Kristian W PajtlerDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Kendra K MaaßDivision of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg 69120, Germany.
Katharina Clemm von HohenbergJunior Clinical Cooperation Unit Translational Lymphoma Research, German Cancer Research Center (DKFZ) Heidelberg, Mannheim 68169, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cfDNAEV preservationextracellular vesicleshuman plasmaisolation protocolliquid biopsypreanalyticstranslation

Identifiers

PMID41551608
PMCPMC12809394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.