Evidence map›Paper›PMID 41551594›Full record

ReviewExtracellular vesicles and circulating nucleic acids2025

Overview of extracellular vesicles as biomarkers and therapeutic tools in pediatric diseases: focus on the gut-lung axis.

Paola Bisaccia, Alice Zaramella, Agner Henrique Dorigo Hochuli, Raquel Moll Diaz, Miriam Duci, Maurizio Muraca, Eugenio Baraldi, Michela Pozzobon

Abstract readReview
In one paragraph

Review in Extracellular vesicles and circulating nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microbial extracellular vesicles in the lung: friends in health, agents in disease.Extracellular vesicles and circulating nucleic acids · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paola BisacciaDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Alice ZaramellaDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Agner Henrique Dorigo HochuliDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Raquel Moll DiazDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Miriam DuciDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Maurizio MuracaDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Eugenio BaraldiDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.
Michela PozzobonDepartment of Women's and Children's Health, University of Padova, Padova 35129, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although anatomically separate, the gut and lungs are interconnected through intricate pathways involving their respective microbiota, supporting the concept of a gut-lung axis. In the pediatric field, devastating intestinal pathologies such as necrotizing enterocolitis and inflammatory bowel diseases mostly affect preterm infants. In parallel, in the lung, bronchopulmonary dysplasia and chronic obstructive pulmonary disease represent pediatric unmet clinical needs. In this review, we discuss how the extracellular vesicles (EVs), nanoparticles secreted by all cell types, represent a common element in the gut-lung axis. Specifically, EVs play a dual role, serving both as novel disease biomarkers and as promising therapeutic agents.

Indexed as

bronchopulmonary dysplasiachronic obstructive pulmonary diseaseextracellular vesiclesGutinflammatory bowel diseaselungnecrotizing enterocolitis

Identifiers

PMID41551594
PMCPMC12809682

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.