Evidence map›Paper›PMID 41551535›Full record

ArticleWorld journal of gastroenterology2026

Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and

Hong Qin, Yi-Yang Liu, Qiang Li, Sai-Yan Wei, Li-Yun Huang, Chai-Feng Zhou, Li-Yan Tan, Jing-Wen Zhang, De-Kun Wu, You-Ming Tang

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Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hong QinGraduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
Yi-Yang LiuGraduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
Qiang LiDepartment of Digestive Disease, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China.
Sai-Yan WeiDepartment of Digestive Disease, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China.
Li-Yun HuangGraduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
Chai-Feng ZhouGraduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
Li-Yan TanGraduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
Jing-Wen ZhangGraduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
De-Kun WuTeaching Experiment and Training Center, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China.
You-Ming TangDepartment of Digestive Disease, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic atrophic gastritis (CAG) is a clinically refractory gastric disease often characterized by high recurrence rates and adverse drug reactions. Anwei decoction (AWD), a traditional Chinese medicine formula, has been shown to significantly improve clinical symptoms in patients with CAG, as demonstrated by a multicenter cohort study (overall effective rate: 82.5%,

aimTo investigate the therapeutic mechanisms of AWD against CAG from an integrated perspective.

methodsIn this study, N-methyl-N'-nitro-N-nitrosoguanidine was used to establish a CAG rat model. Serum-derived constituents transferred from AWD were first identified using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. The concentrations of inflammatory cytokines in serum samples were determined by enzyme-linked immunosorbent assay. Moreover, gastric mucosal tissues were analyzed by quantitative real-time polymerase chain reaction to measure messenger RNA (mRNA) levels of the

resultsAWD notably reduced serum levels of pro-inflammatory cytokines, such as IL-1β, IL-18, tumor necrosis factor-α, and lipopolysaccharide, demonstrating significant statistical differences (all

conclusionAWD alleviates the pathological progression of CAG through multi-target synergistic mechanisms. On one hand, AWD directly suppresses gastric mucosal inflammation by inhibiting

Indexed as

Drugs, Chinese HerbalGastritis, AtrophicGastrointestinal MicrobiomeInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsChronic DiseaseCytokinesDisease Models, AnimalGastric MucosaHumansMaleMethylnitronitrosoguanidineRatsRats, Sprague-DawleyCytokinesDrugs, Chinese HerbalInflammasomesMethylnitronitrosoguanidineNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratAnwei decoctionChronic atrophic gastritisGut microbiota-metabolite axisNLRP3 inflammasomeTraditional Chinese medicine

Identifiers

PMID41551535
PMCPMC12809159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.