ReviewFrontiers in medicine2025
The role of ferroptosis in osteoporosis: from pathogenic mechanisms to natural product-driven therapeutic innovations.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Targeting ferroptosis in osteoporosis: mechanisms and natural products therapies.Frontiers in pharmacology · 2026Review
- Mitochondrial dysfunction and the regulatory cell death crosstalk network in chronic obstructive pulmonary disease: from oxidative stress mechanisms to targeted therapeutic strategies.Frontiers in immunology · 2026Review
- The estrogen-ferroptosis axis in postmenopausal osteoporosis, osteoarthritis, and intervertebral disc degeneration: shared mechanisms and emerging evidence.Frontiers in immunology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is, a common bone disease, and it has become a prominent health problem of the elderly in modern society. As a new type of cell death, ferroptosis plays an important role in the occurrence and development of osteoporosis. Therefore, regulation of iron metabolism is helpful for the treatment of osteoporosis. This article not only reviews the molecular mechanism of ferroptosis in osteoporosis, but also focuses on the three-dimensional regulatory network of iron metabolism disorder, lipid peroxidation, and bone homeostasis imbalance. Natural active ingredients with potential inhibiting ferroptosis, including traditional Chinese medicine, and their corresponding targets, are also evaluated from the perspective of natural product chemistry and molecular pharmacology. Finally, the research and development prospects of natural ingredient delivery systems in the treatment of osteoporosis are discussed. Advances in these therapeutic strategies provide new opportunities to address the challenges in the management of osteoporosis and may improve the quality of life of elderly patients. This article comprehensively reviews the related studies of ferroptosis and osteoporosis, providing a valuable reference for research and clinical practice in this field, and contributing to the further development of osteoporosis treatment research.
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Registered trials
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