Evidence map›Paper›PMID 41551492›Full record

ArticleJournal of applied crystallography2025

Exploring humidity effects on polycrystalline human insulin-ligand complexes: preliminary crystallographic insights.

Angelos Kontarinis, Christina Papaefthymiou, Stamatina Kafetzi, Marios Konstantopoulos, Dimitris Koutoulas, Max Nanao, Gerd Schluckebier, Mathias Norrman, Natalia Dadivanyan, Detlef Beckers and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied crystallography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Angelos KontarinisDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.
Christina PapaefthymiouDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.ORCID https://orcid.org/0009-0008-7836-0424
Stamatina KafetziDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.
Marios KonstantopoulosDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.
Dimitris KoutoulasDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.
Max NanaoEuropean Synchrotron Radiation Facility (ESRF) 71 Avenue des Martyrs Grenoble F-38000 France.
Gerd SchluckebierTherapeutic Discovery Novo Nordisk A/S Novo Nordisk Park Malov DK 2760 Denmark.ORCID https://orcid.org/0000-0003-0725-4081
Mathias NorrmanDiabetes Protein Engineering Novo Nordisk A/S Novo Nordisk Park Malov DK 2760 Denmark.
Natalia DadivanyanMalvern Panalytical BV, Lelyweg 1, Almelo, 7602 EA, The Netherlands.
Detlef BeckersMalvern Panalytical BV, Lelyweg 1, Almelo, 7602 EA, The Netherlands.
Thomas DegenMalvern Panalytical BV, Lelyweg 1, Almelo, 7602 EA, The Netherlands.ORCID https://orcid.org/0009-0007-2211-3179
Eleftheria RosmarakiDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.
Andrew FitchEuropean Synchrotron Radiation Facility (ESRF) 71 Avenue des Martyrs Grenoble F-38000 France.ORCID https://orcid.org/0000-0002-9768-5688
Irene MargiolakiDepartment of Biology, Section of Genetics, Cell Biology and Development University of Patras Patras GR-26500 Greece.ORCID https://orcid.org/0000-0003-4455-6054

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the effect of relative humidity (RH) on the crystal structures of human insulin (HI) complexes with organic ligands,

Indexed as

human insulin complexesin situX-ray powder diffractionligand bindingpharmaceutical crystallographyprotein crystallographyprotein–ligand interactionsrelative humidity effectsSCXRDsingle-crystal X-ray diffractionstructural stabilityunit-cell variationXRPD

Identifiers

PMID41551492
PMCPMC12810493

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.