Evidence map›Paper›PMID 41551444›Full record

ArticlePeerJ2026

MRS2 and mitochondrial gene networks in endometrial cancer: mechanisms, biomarkers, and therapeutic implications.

Leyi Huang, Yafang Kang, Wenyu Lin, Jiaxi Chen, Yuxuan Huang, Yan Zhang, Yihan Shen, Zeyu Wu, Sihao Chen, Shaoqing Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Leyi Huang *Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Yafang Kang *Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Wenyu LinMedical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian, China.
Jiaxi ChenDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Yuxuan HuangLaboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Yan ZhangThe State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Yihan ShenDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Zeyu WuDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Sihao ChenDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Shaoqing ZhengDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Yiyang WangDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Renxi LinDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.
Yuanlin QiDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium ions and their transport proteins are increasingly recognized for their critical roles in tumor progression. However, their specific mechanisms in endometrial cancer (EC) remain poorly understood. This study investigated the role of Mitochondrial RNA Splicing 2 protein (MRS2), a key mitochondrial magnesium transporter, and its associated genes, in regulating mitochondrial function and the invasive and metastatic capabilities of EC cells. Using a combination of experimental approaches including lactate detection, flow cytometry, immunofluorescence, CCK8 assays, and Transwell migration assays, along with bioinformatics analysis, we investigated the relationship between lactate levels and MRS2 expression in endometrial cancer cells (KLE). Our findings suggest that elevated lactate levels are associated with increased MRS2 expression in mitochondria. This correlation was further linked to enhanced reactive oxygen species (ROS) production and altered expression of mitochondrial-related genes. Notably, MRS2 knockdown resulted in reduced proliferation of KLE cells, supporting a potential functional role of MRS2 in endometrial cancer progression. These findings provide new insights into the molecular mechanisms underlying EC progression and highlight MRS2 as a potential therapeutic target.

Indexed as

Cation Transport ProteinsEndometrial NeoplasmsGene Regulatory NetworksMitochondriaMitochondrial ProteinsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansLactic AcidReactive Oxygen SpeciesBiomarkers, TumorCation Transport ProteinsLactic AcidMitochondrial ProteinsReactive Oxygen SpeciesEndometrial cancerMagnesium ionMitochondrionMRS2ROS

Identifiers

PMID41551444
PMCPMC12805914

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.