Evidence map›Paper›PMID 41551210›Full record

ArticleMediators of inflammation2026

Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low-Intensity Pulsed Ultrasound and Imipenem.

Wentao Tang, Juan Deng, Xinyi Zhang, Guolin Song, Juan Qin, Chenghai Li, Xinfang Xiao, Liu Wu, Yilin Tang, Yiqing Zhou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wentao TangState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Juan DengState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Xinyi ZhangState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Guolin SongDepartment of Emergency, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou, 550003, China, gzu.edu.cn.
Juan QinDepartment of Obstetrics and Gynecology, Guiyang Maternal and Child Health Care Hospital, Guizhou Medical University, Guizhou, 550003, China, gmc.edu.cn.
Chenghai LiState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Xinfang XiaoState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Liu WuState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Yilin TangState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Yiqing ZhouState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Junfen LiState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Sicheng HeState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.
Yan WangState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China, cqmu.edu.cn.ORCID https://orcid.org/0000-0001-6555-9946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: This study aimed to investigate the effects of low intensity pulsed ultrasound (LIPUS) combined with imipenem (IMI) on inflammatory responses and organ protection in septic rats. Results: The study involved 230 Sprague-Dawley (SD) rats, with 80 used for survival analysis and 150 for sampling over 72 h. Histological examination (hematoxylin and eosin [H&E] staining) and transmission electron microscopy (TEM) revealed that LIPUS combined with IMI significantly alleviated spleen tissue damage and reduced mitochondrial edema. Key inflammatory cytokines, such as interleukin-1 beta (IL-1 Conclusion and Innovation: This study presents a novel approach by integrating LIPUS with IMI, providing a noninvasive and effective strategy to mitigate cytokine storms, optimize antibiotic use, and reduce organ damage in sepsis. The protective effects observed are primarily attributed to the inhibition of the IL-1R/NF-

Indexed as

Cytokine Release SyndromeCytokinesImipenemSepsisUltrasonic WavesAnimalsHMGB1 ProteinInflammationInterleukin-10Interleukin-1betaInterleukin-6MaleNF-kappa BRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaCytokinesHMGB1 ProteinImipenemInterleukin-10Interleukin-1betaInterleukin-6NF-kappa BTumor Necrosis Factor-alphaIL-1R/NF-κB signaling pathwayIMIinflammationlow-intensity ultrasoundsepsis

Identifiers

PMID41551210
PMCPMC12809473

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.