Recurrent uterine adenofibroma revealed to be hyperparathyroidism-jaw tumor syndrome: Case report.

Go Nakai, Takashi Yamada, Tomohito Tanaka, Kazuhiro Yamamoto, Keigo Osuga

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Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Go NakaiDepartment of Diagnostic Radiology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

Takashi YamadaDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

Tomohito TanakaDepartment of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

Kazuhiro YamamotoDepartment of Diagnostic Radiology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

Keigo OsugaDepartment of Diagnostic Radiology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine adenofibroma was previously classified as a benign mixed epithelial and mesenchymal tumor, but the WHO removed it from its fifth edition due to diagnostic overlap with low-grade adenosarcoma or benign polyps. We report a case of a 21-year-old woman with a recurrent uterine polypoid tumor initially diagnosed as adenofibroma on biopsy and resected multiple times. MRI revealed heterogeneous intrauterine masses with cystic changes, and PET-CT showed weak FDG uptake. Eventually, hysterectomy confirmed adenofibroma. She also had a prior diagnosis of primary hyperparathyroidism caused by parathyroid adenoma. Due to the early onset and recurrent uterine tumors, hyperparathyroidism-jaw tumor syndrome (HPT-JT) was suspected. Immunohistochemistry showed loss of parafibromin expression in the uterine tumor, supporting the diagnosis. This case highlights the importance of considering genetic syndromes such as HPT-JT in young patients with recurrent uterine tumors, enabling appropriate surveillance for associated neoplasms in the parathyroid, jaw, and kidneys.

Indexed as

AdenofibromaCase reportHyperparathyroidism–jaw tumor syndromeImagingUterus

Identifiers

PMID41551103

DOI10.1016/j.radcr.2025.12.015

PMCPMC12809490

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