ArticleInfectious diseases & clinical microbiology2025
Changing HIV Epidemiology: A Retrospective Analysis of a Single-Center Experience.
Article in Infectious diseases & clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: In recent decades, the global HIV epidemic has undergone significant changes in transmission patterns, demographics, and clinical outcomes. Understanding regional epidemiological trends is essential for shaping effective public health strategies. This study aimed to evaluate the 20-year epidemiological and clinical trends of people living with HIV (PLWH) followed in a tertiary center in Türkiye. Materials and Methods: This retrospective cohort study included PLWH followed at a tertiary hospital between 2005 and 2024. The study period was divided into two decades: 2005-2014 (the first period) and 2015-2024 (the second period). Demographic, clinical, and laboratory data were collected and compared between the two periods. Results: Of the 160 patients included in the study, 84.4% were male, with a median age of 42 years. A significant increase in new HIV diagnoses was observed in the second period (n=129 vs. n=31). Patients in the second period were younger (median 38 vs. 49 years, Conclusion: The HIV epidemic in this region has evolved significantly over the past two decades. While improvements in early diagnosis and access to treatment reflect public health success, the changing demographics and transmission dynamics highlight the need for targeted prevention strategies. These findings underscore the importance of adapting public health responses to the evolving characteristics of the HIV epidemic. Graphic Abstract: Graphic Abstract.
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