ArticleAddictive behaviors reports2026
Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample.
Shelley Alyse Gresko, Robin P Corley, Erik G Willcutt, Michael C Stallings, Christian J Hopfer, Soo Hyun Rhee
Abstract read
In one paragraphArticle in Addictive behaviors reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Shelley Alyse GreskoDepartment of Psychology and Neuroscience, University of Colorado Boulder, Muenzinger D244 345 UCB Boulder, CO, USA 80309-0345.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St Boulder, CO, USA 80303.
Erik G WillcuttDepartment of Psychology and Neuroscience, University of Colorado Boulder, Muenzinger D244 345 UCB Boulder, CO, USA 80309-0345.
Michael C StallingsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Muenzinger D244 345 UCB Boulder, CO, USA 80309-0345.
Christian J HopferInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St Boulder, CO, USA 80303.
Soo Hyun RheeDepartment of Psychology and Neuroscience, University of Colorado Boulder, Muenzinger D244 345 UCB Boulder, CO, USA 80309-0345.
Funding
VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9MTwin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MColorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5MRocky Mountain Cannabis Research CenterP50DA056408 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Angela Bryan · 2023 to 2026
$14.0MResearch Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3MUnderstanding the links between parental and adolescent substance use:complementary natural experiments using the children of twins designR01DA054087 · NIDA · UNIVERSITY OF COLORADO · PI Matthew Charles Keller, SOO H RHEE · 2022 to 2026
$4.9MGenetics and Progression of Early-onset Substance Dependence and HIV RiskR01DA035804 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J, STALLINGS, MICHAEL CRAIG · 2014 to 2018
$4.9MAdult Progression of Adolescent Onset Substance Use Disorder in a High Risk SampleR01DA053693 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Christian J Hopfer, Michael Craig Stallings · 2022 to 2026
$3.2MEffects of High Potency Cannabis Products on Mental Health and Psychosocial FunctioningR01DA057894 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Christian J Hopfer · 2023 to 2026
$2.7MNIA NIH HHS R01 AG046938NICHD NIH HHS P50 HD027802NIDA NIH HHS P50 DA056408NIDA NIH HHS P60 DA011015NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA053693NIDA NIH HHS R01 DA054087NIDA NIH HHS R01 DA057894NIDA NIH HHS T32 DA017637
6 · The paper itselfAbstract
Background: Subjective effects (SEs) are positively associated with substance use disorders in clinical samples. However, the etiology of these associations remains unclear. The present study utilized a clinical sample selected for elevated polysubstance use disorder (SUD) criteria to address the following questions: Are positive and negative polysubstance SEs and SUD criteria associated? Are cross-sectional and longitudinal results consistent? Is there evidence for common genetic influences between SEs and SUDs? Methods: Cross-sectional and longitudinal analyses using the Defries Fulker regression method were conducted in clinical probands ( Results: SEs were correlated with SUD criteria from adolescence to adulthood in clinical probands ( Conclusions: Elevated SUDs and SEs were mostly explained by familial influences independent of genetics. There was little support for common genetic influences on elevated SUDs and SEs, possibly due to low power. Future research should focus on individual factors driving associations between these constructs.
Indexed as
Behavior geneticsClinical sampleLongitudinalPolysubstance useSubjective effectsSubstance use disorder
Identifiers
PMID41551024
PMCPMC12811426
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