Evidence map›Paper›PMID 41551022›Full record

ArticleRSC medicinal chemistry2026

Potent and selective indole-based inhibitors targeting disease-transmitting mosquitoes.

R Rajeshwari, V Duvauchelle, C Lindgren, K Stangner, S Knutsson, N Forsgren, F Ekström, L Kamau, A Linusson

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

R RajeshwariDepartment of Chemistry, Umeå University Sweden anna.linusson@umu.se.
V DuvauchelleDepartment of Chemistry, Umeå University Sweden anna.linusson@umu.se.ORCID https://orcid.org/0000-0003-1227-0262
C LindgrenDepartment of Chemistry, Umeå University Sweden anna.linusson@umu.se.ORCID https://orcid.org/0000-0002-7907-9318
K StangnerDepartment of Chemistry, Umeå University Sweden anna.linusson@umu.se.
S KnutssonDepartment of Chemistry, Umeå University Sweden anna.linusson@umu.se.
N ForsgrenSwedish Defense Research Agency Umeå Sweden.
F EkströmSwedish Defense Research Agency Umeå Sweden.
L KamauCentre of Biotechnology Research and Development, Kenya Medical Research Institute Nairobi Kenya.
A LinussonDepartment of Chemistry, Umeå University Sweden anna.linusson@umu.se.ORCID https://orcid.org/0000-0003-0063-8912

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vector control with insecticides is an important preventive measure against mosquito-borne infectious diseases, such as malaria and dengue. The intensive usage of few insecticides has resulted in emerging resistance in mosquitoes, and unwanted off-target toxic effects. Therefore, there is great interest in alternative active ingredients. Here, we explore indole-based compounds as selective inhibitors against acetylcholinesterase 1 (AChE1) from the disease-transmitting mosquitoes

Identifiers

PMID41551022
PMCPMC12805588

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.