Evidence map›Paper›PMID 41551016›Full record

ArticleChinese medical journal pulmonary and critical care medicine2025

Type 2 inflammation in chronic obstructive pulmonary disease: A promising treatable trait and practice recommendations.

Yan Chen, Ting Yang, Jing Zhang, Xiangqi Chen, Xin Chen, Zhe Cheng, Yaqing Li, Xiaoyun Fan, Wei Han, Zhiyi He and 41 more

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Article in Chinese medical journal pulmonary and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Yan ChenDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Research Unit of Respiratory Disease, Central South University; Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province; Diagnosis and Treatment Center of Respiratory Disease in Hunan Province, Changsha, Hunan 410011, China.
Ting YangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Jing ZhangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xiangqi ChenDepartment of Pulmonary and Critical Care Medicine, Fujian Medical University Union Hospital; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, Fuzhou, Fujian 350001, China.
Xin ChenDepartment of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China.
Zhe ChengDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yaqing LiDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China.
Xiaoyun FanDepartment of Geriatric Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University; Anhui Geriatric Institute; Key Laboratory of Respiratory Diseases Research and Medical Transformation of Anhui Province, Hefei, Anhui 230022, China.
Wei HanDepartment of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, School of Medicine, Qingdao Key Lab for Common Diseases, Qingdao Hospital, University of Rehabilitation and Health Sciences; School of Public Health, Qingdao University, Qingdao, Shandong 266071, China.
Zhiyi HeDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Dedong MaDepartment of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Ying MengDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Junxia YanDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Hunan Provincial Key Laboratory of Clinical Epidemiology, Central South University, Changsha, Hunan 410013, China.
Yan YinDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Huihui ZengDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Research Unit of Respiratory Disease, Central South University; Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province; Diagnosis and Treatment Center of Respiratory Disease in Hunan Province, Changsha, Hunan 410011, China.
Qiong ZhouDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Xiaoming ZhouRespiratory Department, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
Hui CaiDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yanan CuiNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Yiming MaDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Research Unit of Respiratory Disease, Central South University; Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province; Diagnosis and Treatment Center of Respiratory Disease in Hunan Province, Changsha, Hunan 410011, China.
Fuqiang WenDepartment of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Yongchang SunDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.
Dejun SunDepartment of Pulmonary and Critical Care Medicine/Key Laboratory of National Health Commission for the Diagnosis & Treatment of COPD, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017, China.
Xiaoju LiuDepartment of Gerontal Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
Jinping ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Wei WangDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Zeguang ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Xixin YanThe First Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Respiratory Critical Care Medicine, Hebei Institute of Respiratory Diseases, Shijiazhuang, Hebei 050000, China.
Shaoxi CaiDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Jie CaoDepartment of Respiratory Medicine, The General Hospital of Tianjin Medical University, Tianjin 300052, China.
Yuanlin SongDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Jianping ZhaoDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Yumin ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Huili ZhuDepartment of Pulmonary Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Manxiang LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Yanfei GuoDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China.
Qianli MaDepartment of Respiratory and Critical Care Medicine, Songshan General Hospital, Chongqing 401120, China.
Zhenyu LiangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Li ZhaoDepartment of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Yahong ChenDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.
Jianmiao WangDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Fengyan WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Yuqiong YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Huajing YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Jian KangDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Rongchang ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Assembly of Chronic Obstructive Pulmonary Disease (COPD) of Chinese Thoracic Society (CTS)
COPD Working Group of Chinese Association of Chest Physician (CACP) of the Chinese Medical Doctor Association
Evidence-Based Medicine Group of the Clinical Epidemiology Branch of the Chinese Medical Association
Respiratory Disease Control Committee of the Chinese Preventive Medicine Association
Precision Medicine Group of the Respiratory Disease Committee of the Cross-Strait Medical and Health Exchange Association

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 2 inflammation is a key inflammatory endotype of chronic obstructive pulmonary disease (COPD). The precise identification and targeted intervention of treatable traits related to type 2 inflammation are crucial directions in the current management of COPD. Recently, a growing body of evidence-based medical data has accumulated regarding the clinical characteristics, biomarkers, therapeutic agents, and efficacy evaluation of type 2 inflammation in COPD, providing strong support for clinical diagnosis and treatment. This clinical practice recommendation systematically reviewed the evidence-based medical literature and integrated clinical experience to present expert opinions, aiming to standardize and improve the management of type 2 inflammation in COPD. Methods: This clinical practice recommendation followed Appraisal of Guidelines for Research and Evaluation II (AGREE II) and the Reporting Items for Practice Guidelines in HealThcare (RIGHT) statement to ensure the thoroughness and transparency. Clinical questions were primarily derived from surveys among experts in the field and thorough discussion at meetings. The evidence grading levels and recommendation grades adopted in the clinical practice recommendation follow the evidence grading levels and recommendation grades established by the Oxford Centre for Evidence-Based Medicine. The expert opinions were formulated through open discussion and expert voting. Expert opinions with an agreement rate of 80 % or higher among the experts are incorporated in the clinical practice recommendation. Results: Eight clinical questions concerning diagnosis and treatment were proposed after expert discussion. In addition, fifteen specific major points of expert opinions about type 2 inflammation in COPD, involving clinical features, biomarkers, correlation with clinical outcomes, inhaled corticosteroid (ICS) treatment, biologic treatment and treatment response, were determined. Conclusions: A set of comprehensive clinical practice recommendations focusing on the treatable trait of type 2 inflammation in COPD was established, which may provide potential guidance for the precision management of COPD.

Indexed as

Chronic obstructive pulmonary diseaseDiagnosisTreatmentType 2 inflammation

Identifiers

PMID41551016
PMCPMC12805407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.