ArticleAntibody therapeutics2026
The development of a next generation NK cell engager platform by integrating a potency-reduced IL-15 variant to enhance antitumor activity.
Article in Antibody therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Natural killer cell engager (NKCE) has gained attention recently. Conventional NKCEs exhibit mild anti-tumor efficacy despite acceptable safety profiles. Therefore, next-generation NKCE development is essential to enhance efficacy. IL-15, a key NK cell activator, is explored in NKCE design. However, wild-type IL-15 shows significant toxicity in clinical trials. In this study, we present the development of a novel tetravalent NKCE platform (IL15v-NKCE) by incorporating a potency-reduced IL-15 element (IL15v) into our proprietary anti-NKp46 based NKCEs. Methods: The activity of the IL15v moiety was assessed by quantifying pSTAT5 induction in primary immune cells and evaluating STAT5 activation in an IL-15 reporter cell line. The Results: Conclusions: By integrating IL15v into our anti-NKp46 based NKCEs, IL15v-NKCE has exhibited enhanced anti-tumor efficacy while maintaining an acceptable safety profile, thereby positioning it as a promising next-generation therapeutic modality for NK cell-based therapy.
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