Evidence map›Paper›PMID 41550954›Full record

ArticleFrontiers in immunology2025

Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of

Kristina N Delgado, Crystal F Vicente, Carson J La Vake, Everton Bettin, Melissa J Caimano, Justin D Radolf, Kelly L Hawley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The Global Syphilis Epidemic: Turning the Tide.Sexually transmitted diseases · 2026
    Article
  3. Review
  4. TheJornal brasileiro de doencas sexualmente transmissiveis : DST · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristina N DelgadoDepartment of Pediatrics, UConn Health, Farmington, CT, United States.
Crystal F VicenteDepartment of Pediatrics, UConn Health, Farmington, CT, United States.
Carson J La VakeDepartment of Pediatrics, UConn Health, Farmington, CT, United States.
Everton BettinDepartment of Medicine, UConn Health, Farmington, CT, United States.
Melissa J CaimanoDepartment of Pediatrics, UConn Health, Farmington, CT, United States.
Justin D RadolfDepartment of Pediatrics, UConn Health, Farmington, CT, United States.
Kelly L HawleyDepartment of Pediatrics, UConn Health, Farmington, CT, United States.

Funding

Prevalence of syphilis and other sexually transmitted infections in men and transgender women who have sex with men in Cali, ColombiaU19AI144177 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MOODY, MICHAEL ANTHONY, RADOLF, JUSTIN D · 2019 to 2023
$11.2M
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidumU01AI182179 · NIAID · DUKE UNIVERSITY · PI Michael Anthony Moody, Justin D Radolf · 2024 to 2026
$6.9M
NIAID NIH HHS U01 AI182179NIAID NIH HHS U19 AI144177
6 · The paper itself

Abstract

A vaccine is urgently needed to curtail the global epidemic of syphilis, a sexually transmitted infection caused by the spirochetal pathogen

Indexed as

Antibodies, BacterialAntibodies, NeutralizingBacterial Outer MembraneBacterial Outer Membrane ProteinsSyphilisTreponema pallidumAnimalsBacterial VaccinesRabbitsAntibodies, BacterialAntibodies, NeutralizingBacterial Outer Membrane ProteinsBacterial Vaccinesextracellular loopFadLgrowth inhibitionouter membrane damagesyphilisTreponema pallidum

Identifiers

PMID41550954
PMCPMC12808356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.