Evidence map›Paper›PMID 41550946›Full record

ArticleFrontiers in immunology2025

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model.

Patricia Cuenca-Lara, Miriam Blay-Benach, Zoraida Cervera, Julia Moraleda, Iker A Sevilla, Joseba M Garrido, Mahavir Singh, Sergio López-Soria, Enric Vidal, Mariano Domingo and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Phagocytosis ofInternational journal of molecular sciences · 2026
    Article
  3. Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patricia Cuenca-Lara *Unitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Miriam Blay-Benach *Unitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Zoraida CerveraUnitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Julia MoraledaUnitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Iker A SevillaAnimal Health Department, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, Spain.
Joseba M GarridoAnimal Health Department, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, Spain.
Mahavir SinghLionex Diagnostics and Therapeutics GmbH, Braunschweig, Germany.
Sergio López-SoriaUnitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Enric VidalUnitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Mariano DomingoUnitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Bernat Pérez de ValUnitat Mixta d'Investigació Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-UAB en Sanitat Animal, CReSA, Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early immune containment of mycobacteria at the infection site is key to tuberculosis (TB) vaccine development. Intranasal delivery strategies offer a promising alternative to parenteral BCG vaccination, particularly for pulmonary TB, the predominant clinical form in humans and livestock. This study evaluated the immunogenicity of intranasal BCG and heat-inactivated

Indexed as

BCG VaccineImmunity, MucosalLungMycobacterium bovisRespiratory MucosaTuberculosisTuberculosis, PulmonaryAdministration, IntranasalAnimalsCytokinesDisease Models, AnimalGoatsMacrophages, AlveolarVaccinationBCG VaccineCytokinesalveolar macrophagesanimal modelBCGgoatheat-inactivated Mycobacterium bovismucosal immunitymucosal vaccinestuberculosis

Identifiers

PMID41550946
PMCPMC12808410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.