ArticleFrontiers in immunology2025
Pox-AbDab: the orthopoxvirus antibody database.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential therapeutic interventions. Here, we presented the Orthopoxvirus Antibody Database (Pox-AbDab), a repository of data on antibodies known to bind or neutralise viruses from the same genus as mpox (https://opig.stats.ox.ac.uk/webapps/poxabdab). Beyond standardising and centralising the data, we highlighted challenges in translating knowledge across orthopoxviruses, such as the absence of a function-based nomenclature for virion surface antigens. We also performed an exploratory analysis of the known orthopoxvirus-binding antibody landscape, highlighting their aggregate molecular properties, cross-binding/cross-neutralisation profiles, evidence for immunodominance or immune escape from their epitopes, and gaps in coverage to help orient future research. Systematic review: Code available at: https://opig.stats.ox.ac.uk/webapps/poxabdab.
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