ArticleFrontiers in immunology2025
The neoadjuvant esophageal score: a prognostic tool for predicting survival and postoperative complications in esophageal squamous cell carcinoma.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Development of a prognostic prediction model incorporatingJournal of gastrointestinal oncology · 2026Article
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11 authors.
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Abstract
Background: Esophageal squamous cell carcinoma (ESCC) remains a major global health challenge, and reliable prognostic markers. We developed and validated the Neoadjuvant Esophageal (NAE) score, derived from treatment response, to predict overall survival (OS) and postoperative complications in locally advanced ESCC. Methods: We retrospectively analyzed 411 patients with ESCC from four hospitals who underwent esophagectomy following neoadjuvant therapy between July 2013 and November 2020. Patients were stratified into low-, intermediate-, and high-score groups. OS was assessed using Kaplan-Meier and Cox regression analyses, and predictive models were constructed with nomograms. Model performance was evaluated using concordance index (C-index), ROC curves, calibration plots, and decision curve analysis. Results: The NAE score effectively stratified survival outcomes (5-year OS, Conclusion: The NAE score is a robust prognostic tool for patients with locally advanced ESCC, capable of predicting survival, guiding adjuvant therapy, and estimating risk of severe postoperative complications. Its integration into clinical practice could refine risk stratification and support personalized treatment strategies, with prospective validation warranted.
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