ArticleACS materials Au2026
Investigation of Transdermal Drug Delivery and In Vivo Pharmacokinetics of Choline Ketoprofen Ionic Liquid.
Article in ACS materials Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
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Abstract
To solve the bioavailability of nonsteroidal anti-inflammatory drugs and reduce their clinical risks, this study combined density functional theory (DFT) calculations with experiments and investigated the mechanism of in vitro transdermal absorption of choline ketoprofen gel and the pharmacokinetics of choline ketoprofen in rats. High-performance liquid chromatography (HPLC) was used to analyze the in vitro transdermal effect of ketoprofen in rats and the concentration of ketoprofen in the plasma of rats, which were administered choline ketoprofen by gavage. After the transdermal treatment, the rat skin was subjected to Hematoxylin and Eosin (H&E) staining and observe changes in skin structure. The results indicate that choline ketoprofen gel is superior to ketoprofen gel in terms of transdermal ability. Its transdermal rate is 1.4-2.2 times that of ketoprofen gel. The results show that the interaction force between choline ketoprofen and phospholipids is approximately 2.5 times that between ketoprofen and phospholipids, causing edema in epidermal cells and the dermis, which enlarges the intercellular space and then enhances the transdermal absorption capacity of ketoprofen. Compared with the ketoprofen suspension, the peak concentration of ketoprofen increased from 7.708 to 39.495 mg·L
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