Evidence map›Paper›PMID 41550864›Full record

ReviewFrontiers in nutrition2025

Impact of the flavonoid-induced intestinal microbiota modulation on global energy metabolism: implication for obesity.

Omar Guzmán-Quevedo, Alana Natalícia Vasconcelos de Araújo, Pedro A Romero-Juárez, Jordania Candice Costa Silva, Gonzalo Soria-Melgarejo, Luz Torner, Jailane de Souza Aquino

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Omar Guzmán-QuevedoLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM)/Instituto Tecnológico Superior de Tacámbaro, Tacámbaro, Michoacán, Mexico.
Alana Natalícia Vasconcelos de AraújoLaboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
Pedro A Romero-JuárezLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM)/Instituto Tecnológico Superior de Tacámbaro, Tacámbaro, Michoacán, Mexico.
Jordania Candice Costa SilvaLaboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
Gonzalo Soria-MelgarejoTecnológico Nacional de México (TECNM)/Instituto Tecnológico Superior de Puruándiro, Puruándiro, Michoacán, Mexico.
Luz TornerCentro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia, Michoacán, Mexico.
Jailane de Souza AquinoLaboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence from the literature clearly demonstrates the beneficial effects of flavonoids on energy metabolism. Due to this, they have become important candidates for combating metabolic disorders like obesity and diabetes. Intestinal microbiota (IM) has shown similar effects on metabolic regulation, contributing to host health. Several studies have shown concomitant effects on metabolism and intestinal microbial profile in response to flavonoid-based treatments. However, the role of the bidirectional interaction between IM and flavonoids in the metabolic effects of these organic compounds is less well-established. This review discusses the effects of flavonoids on the IM in regulating energy homeostasis in metabolically relevant tissues, including skeletal muscle, liver, adipose tissue, and hypothalamus. The modulation of the gut microbiota by dietary flavonoids and

Indexed as

energy metabolismflavonoidsinflammationintestinal microbiotaobesity

Identifiers

PMID41550864
PMCPMC12807911

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.