Evidence map›Paper›PMID 41550856›Full record

ArticleSmall science2026

Novel Respiratory Disease Diagnosis Tool: Development of an Au-ReS

Seokho Jung, Minyoung Ju, Hyunjun Park, Sunggu Kang, Jungbum Kim, Yoseph Seo, Jengmin Kang, Jong Geol Jang, Jung Hyun Choi, Dong Hyung Kim and 4 more

Abstract read
In one paragraph

Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seokho JungDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.
Minyoung JuDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.
Hyunjun ParkDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.ORCID https://orcid.org/0000-0002-8176-0460
Sunggu KangDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.
Jungbum KimDepartment of Chemistry Sungkyunkwan University 2066 Seobu-Ro Jangan-Gu Suwon 16419 Republic of Korea.
Yoseph SeoDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.
Jengmin KangDepartment of Chemistry Sungkyunkwan University 2066 Seobu-Ro Jangan-Gu Suwon 16419 Republic of Korea.
Jong Geol JangDivision of Pulmonology and Allergy Department of Internal Medicine College of Medicine Yeungnam University and Regional Center for Respiratory Diseases Yeungnam University Medical Center 170 Hyeonchung-ro Nam-gu Daegu 42415 Republic of Korea.
Jung Hyun ChoiDivision of Biomedical Metrology Korea Research Institute of Standards and Science 267 Gajeongno Yuseong-Gu Daejeon 34113 Republic of Korea.
Dong Hyung KimDivision of Biomedical Metrology Korea Research Institute of Standards and Science 267 Gajeongno Yuseong-Gu Daejeon 34113 Republic of Korea.
Chulhwan ParkDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.
Min-Ho LeeSchool of Integrative Engineering Chung-Ang University 84 Heukseok-ro Dongjak-Gu Seoul 06974 Republic of Korea.ORCID https://orcid.org/0000-0002-7028-4745
Wonhwa LeeDepartment of Chemistry Sungkyunkwan University 2066 Seobu-Ro Jangan-Gu Suwon 16419 Republic of Korea.ORCID https://orcid.org/0000-0003-4336-5221
Taek LeeDepartment of Chemical Engineering Kwangwoon University 20 Kwangwoon-Ro Nowon-Gu Seoul 01897 Republic of Korea.ORCID https://orcid.org/0000-0003-4158-130X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spirometry is influenced by the patient's subjective condition, which limits the reproducibility of diagnostic results despite being a key diagnostic tool for respiratory diseases. To overcome this, an extended-gate field-effect transistor-type aptasensor for detecting granzyme B (GzmB) and perforin (PRF) is introduced as a proof-of-concept for diagnosing localized immune responses in respiratory diseases. The novel GzmB and PRF aptamers are synthesized using systematic evolution of ligands by exponential enrichment and are subsequently truncated to enhance the target-binding affinity. Au-ReS

Indexed as

dual‐biomarker detecting aptasensorextended‐gate field‐effect transistorgranzyme Bperforinrespiratory disease diagnosis

Identifiers

PMID41550856
PMCPMC12806331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.