ReviewiScience2026
Otubain deubiquitinases: Multi-layered regulators of cell fate, development, and stress responses across kingdoms.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Otubain deubiquitinating enzymes are pivotal regulators of cell fate, development, and stress responses across animals, plants, and fungi. This review highlights their conserved and pleiotropic functions in orchestrating proteostasis, organogenesis, immune modulation, metabolic adaptation, and stress tolerance. Mechanistically, Otubains operate in both enzyme-dependent and -independent manner, modulating key processes including ubiquitin-proteasome-mediated degradation, DNA damage repair, autophagy, and cell death. Notably, Otubains are subject to multi-layered regulations, including epigenetic, transcriptional, post-transcriptional, and post-translational modifications, as well as RNA-mediated scaffolding. In plants, Otubain homologs control grain size and organ morphogenesis, while in fungi, they mediate stress responses and sexual development. These findings underscore the cross-kingdom conservation of Otubain function and reveal their potential as universal modulators. Furthermore, Otubains represent promising targets for therapeutic intervention, crop improvement, and pathogen management. This review synthesizes recent advances in Otubain biology, emphasizing integrative regulatory networks and translational potential, while highlighting key unresolved questions about their functional diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.