Evidence map›Paper›PMID 41550748›Full record

ArticleiScience2026

Comparative proteomic analysis of the ECM composition of the human omentum and mesentery, the main sites of ovarian cancer metastasis.

James M Considine, Clarissa Gomez, Dharma Pally, Ning Yang, Isra N Taha, Jenna Sorenson, Erin G Brooks, Pamela K Kreeger, Alexandra Naba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

James M ConsidineDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL 60612, USA.
Clarissa GomezDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL 60612, USA.
Dharma PallyDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL 60612, USA.
Ning YangDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Isra N TahaDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL 60612, USA.
Jenna SorensonDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Erin G BrooksDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Pamela K KreegerDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Alexandra NabaDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL 60612, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Engineered ECM platforms to analyze progression in high grade serous ovarian cancerR01CA232517 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAMPAGNOLA, PAUL J, KREEGER, PAMELA K · 2018 to 2022
$2.4M
Elevated collagen I and fibronectin in the ovarian cancer pre-metastatic nicheR01CA290693 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Pamela K Kreeger · 2025 to 2026
$1.2M
Acquisition of a Q-Exactive HF Mass SpectrometerS10OD027016 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2019 to 2019
$600k
Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrixR21CA261642 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAO, YU, NABA, ALEXANDRA · 2022 to 2024
$553k
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA232517NCI NIH HHS R01 CA290693NCI NIH HHS R21 CA261642NIH HHS S10 OD023526NIH HHS S10 OD027016
6 · The paper itself

Abstract

Due to its limited symptoms, high-grade serous ovarian cancer (HGSOC) has frequently metastasized extensively throughout the peritoneal cavity prior to its diagnosis, resulting in an overall five-year survival rate of less than 50%. The omentum and mesentery are two of the most common metastatic sites in HGSOC. However, the mechanisms underlying HGSOC metastatic tropism remain unknown. The extracellular matrix (ECM) is a meshwork of proteins that provides biochemical and mechanical signals to cells and has been shown to drive the dissemination of several cancer types to preferential distant sites. Here, combining histological assessment and proteomics, we defined the architectural features and composition of the ECM of paired omentum and mesentery samples from disease-free adult women. We found that over 90% of the proteins detected were shared between the omentum and mesentery, but also identified tissue-specific ECM proteins, including collagen XII and tenascin-C.

Indexed as

CancerProteomics

Identifiers

PMID41550748
PMCPMC12804616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.