Evidence map›Paper›PMID 41550735›Full record

ArticleiScience2026

Autoimmune HLA alleles and neoantigens predict myelodysplastic syndrome outcomes after allogeneic HSCT: A CIBMTR analysis.

Timothy Sears, Razelle Kurzrock, Tao Zhang, Jing Dong, Stephen R Spellman, Aaron M Goodman, Yung-Tsi Bolon, Zhongyuan Chen, Paul Auer, Wael Saber and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Timothy SearsBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
Razelle KurzrockDepartment of Medicine, Medical College of Wisconsin Cancer Center and Genome Sciences and Precision Medicine Center, Milwaukee, WI, USA.
Tao ZhangCIBMTR® (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN, USA.
Jing DongDepartment of Medicine, Medical College of Wisconsin Cancer Center and Genome Sciences and Precision Medicine Center, Milwaukee, WI, USA.
Stephen R SpellmanCIBMTR® (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN, USA.
Aaron M GoodmanDivision of Blood and Marrow Transplantation, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Yung-Tsi BolonCIBMTR® (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN, USA.
Zhongyuan ChenDivision of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA.
Paul AuerCancer Center Biostatistics Shared Resource, Medical College of Wisconsin, Milwaukee, WI, USA.
Wael SaberDepartment of Medicine, Medical College of Wisconsin Cancer Center and Genome Sciences and Precision Medicine Center, Milwaukee, WI, USA.
Hannah CarterBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NTP INFORMATION SYSTEMS SUPPORT27305C0011 · NIEHS · Z-TECH CORPORATION · 2007 to 2009
$4.3M
Prognostic implications of mitochondrial inheritance in myelodysplastic syndromes after stem-cell transplantationK01HL164972 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Jing Dong · 2023 to 2026
$697k
PROVIDE RABBITS, RATS, MICE, HAMSTERS, GERBILS, GUINEA PIGS27307C0011 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$500k
NCI NIH HHS U24 CA076518NHLBI NIH HHS K01 HL164972NIEHS NIH HHS 27305C0011NIEHS NIH HHS 27307C0011NIEHS NIH HHS 27398C0011
6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers curative potential for myelodysplastic syndrome (MDS), despite treatment-related mortality and relapse. We investigated how autoimmune human leukocyte antigen (HLA) alleles and mutanome-derived neoantigens influence post-transplantation outcomes. Donor and recipient HLA alleles, somatic mutations (508 genes; exome sequencing) and clinical covariates (

Indexed as

immune responseimmunologyinterventions

Identifiers

PMID41550735
PMCPMC12804621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.