Evidence map›Paper›PMID 41550677›Full record

ReviewThe World Allergy Organization journal2026

The definition of asthma remission in children: A scoping review by the WAO Paediatric Asthma Committee.

Eleni Anastasiou, Michael Miligkos, Yuichi Adachi, Ignacio J Ansotegui, Héctor A Badellino, Spiros Bekiaris, Zeinab A El-Sayed, Adnan Custovic, Ivana Filipovic, James E Gern and 18 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Update on biologic and small molecules treatments in pediatric allergic diseases.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Eleni AnastasiouAllergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Michael MiligkosAllergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Yuichi AdachiPediatric Allergy Center, Toyama Red Cross Hospital, Toyama, Japan.
Ignacio J AnsoteguiHospital Quironsalud Bizkaia, Erandio, Bilbao, Spain.
Héctor A BadellinoFaculty of Psychology, UCES University, San Francisco, Argentina.
Spiros BekiarisAllergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Zeinab A El-SayedPediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Adnan CustovicNational Heart and Lung Institute, Imperial College London, London, UK.
Ivana FilipovicUniversity Hospital Dr Dragisa Misovic, Belgrade, Serbia.
James E GernDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Rene Maximiliano GómezFaculty of Health Sciences, Catholic University of Salta, Argentina.
Cesar Pozo BeltránPediatric Allergy and Immunology, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Rasha El-OwaidyPediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Elham HossnyPediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Ömer KalayciHacettepe University School of Medicine, Ankara, Turkey.
Peter N Le SouëfSchool of Medicine, University of Western Australia and Telethon Kids Institute, Perth, Western Australia, Australia.
Mário Morais-AlmeidaAllergy Center Hospital CUF-Descobertas, Lisbon, Portugal.
Antonio Nieto-GarciaPediatric Pulmonology and Allergy Unit, Hospital Universitari i Politècnic La Fe, Health Research Institute La Fe, Valencia, Spain.
Paulo M PitrezHospital Santa Casa de Porto Alegre, Porto Alegre, Brazil.
Cristina Rivas-JuesasDepartment of Pediatrics, Hospital de Sagunto, Valencia, Spain.
Alvaro TeijeiroRespiratory Department, Pediatric Hospital, Córdoba, Argentina.
Wanda PhipatanakulDivision of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jiu-Yao WangAllergy, Immunology and Microbiome Research Center, China Medical University Children's Hospital, Taichung, Taiwan.
Gary WongDepartment of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
Paraskevi XepapadakiAllergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Su Boon YongDepartment of Allergy and Immunology, China Medical University Children Hospital, Taichung, Taiwan.
DongKeon YonDepartment of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Nikolaos G PapadopoulosAllergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Asthma remission has emerged as a potential therapeutic goal. However, definitions of remission have primarily focused on adult populations, with limited consensus on how remission should be defined in children. Objective: To comprehensively review how asthma remission has been defined in children and to evaluate consistency and applicability of these definitions. Methods: This scoping review was conducted following PRISMA-ScR guidelines. PubMed MEDLINE was searched for studies published between January 2010 and February 2024. Eligible studies included children with asthma and reported definitions of remission. Key remission criteria were extracted and categorized, and hierarchical cluster analysis was used to identify key patterns. Results: Twenty-nine studies met the inclusion criteria. Most (79.3%) defined paediatric asthma remission based on the absence of clinical symptoms. The most common remission timeframe ranged from 1 to 2 years. A medication-free criterion was used in 68.9% of studies. On-treatment remission was reported in the minority of studies, but it is increasingly acknowledged as a valid outcome. Objective assessments, such as normal lung function (21%) and absence of bronchial hyperresponsiveness (10.3%), were infrequently included. Cluster analysis revealed 3 main patterns for remission definition: symptom-based, event-based, and 1 including objective criteria. Conclusion: Current definitions of asthma remission in paediatric populations are predominantly symptom-based, with limited inclusion of objective physiological measures. Establishing consensus-based definitions for remission tailored to paediatric populations is essential to ensure clinical relevance and alignment with real-world disease patterns.

Identifiers

PMID41550677
PMCPMC12809731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.