Evidence map›Paper›PMID 41550637›Full record

ArticlePharmaceutical science advances2025

Phenol and chromone compounds for

Joan Petrus Oliveira Lima, Caio Henrique Alexandre Roberto, Matheus Nunes da Rocha, Victor Moreira de Oliveira, Rafael Melo Freire, Ralph Santos-Oliveira, Emmanuel Silva Marinho, Pedro de Lima Neto, Pierre Basílio Almeida Fechine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joan Petrus Oliveira LimaAdvanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará - UFC, Campus do Pici, CP 12100, 60451-970, Fortaleza, CE, Brazil.
Caio Henrique Alexandre RobertoPrograma de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará - UECE, Centro de Ciências e Tecnologias - CCT, Av. Dr. Silas Munguba, 1700 - Campus do Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil.
Matheus Nunes da RochaPrograma de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará - UECE, Centro de Ciências e Tecnologias - CCT, Av. Dr. Silas Munguba, 1700 - Campus do Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil.
Victor Moreira de OliveiraPrograma de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará - UECE, Centro de Ciências e Tecnologias - CCT, Av. Dr. Silas Munguba, 1700 - Campus do Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil.
Rafael Melo FreireUniversidad Central de Chile, 8330601, Santiago, Chile.
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.
Emmanuel Silva MarinhoAdvanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará - UFC, Campus do Pici, CP 12100, 60451-970, Fortaleza, CE, Brazil.
Pedro de Lima NetoAdvanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará - UFC, Campus do Pici, CP 12100, 60451-970, Fortaleza, CE, Brazil.
Pierre Basílio Almeida FechineAdvanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará - UFC, Campus do Pici, CP 12100, 60451-970, Fortaleza, CE, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising concern about neglected tropical diseases imposes a global challenge, in this sense, this work brings 12 potential candidates based on chromone and phenol compounds to inhibit nsP2 and nsP3 of the Chikungunya virus (CHIKV), through molecular docking and ADMET evaluation. The molecular docking simulations for the nsP2 showed mild binding, in the nsP3 all the derivatives presented -6 ​kcal/mol binding affinity and interacts with crucial residues in the replication cycle of CHIKV, the 5 best were chosen as the main derivatives for absorption, distribution, metabolism, excretion and toxicity (ADMET) evaluation). The ADMET results show high drug-likeness values, with good oral and intestinal absorption, excretion, distribution and toxicity, with moderate (Der9 to Der12) and poor (Der8) metabolism. Therefore, the 5 derivatives are potential candidates to treat chikungunya.

Indexed as

Chikungunya virusDaldiniaMolecular dockingNatural productsNeglected tropical disease

Identifiers

PMID41550637
PMCPMC12709867

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.