Evidence map›Paper›PMID 41550517›Full record

ArticleKidney international reports2026

Safety and Effectiveness of Long-Term Isoniazid Treatment for the Prevention of Tuberculosis in High-Risk Dialysis Patients.

Robert Freercks, Kathryn Manning, Jason Ensor, Noel Walton, Siviwe Ndamase, Elmi Muller, Savania Nagiah, Andrew D Redd, Elizabeth van der Merwe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert FreercksDepartment of Medicine, School of Medicine, Faculty of Health Sciences, Nelson Mandela University, Gqeberha, South Africa.
Kathryn ManningDepartment of Surgery, University of Cape Town, Faculty of Health Sciences, Groote Schuur Hospital, Cape Town, South Africa.
Jason EnsorDepartment of Medicine, School of Medicine, Faculty of Health Sciences, Nelson Mandela University, Gqeberha, South Africa.
Noel WaltonDivision of Nephrology and Hypertension, Department of Medicine, Livingstone Tertiary Hospital, Gqeberha, South Africa.
Siviwe NdamaseDivision of Nephrology and Hypertension, Department of Medicine, Livingstone Tertiary Hospital, Gqeberha, South Africa.
Elmi MullerFaculty of Medicine, Stellenbosch University, Cape Town, South Africa.
Savania NagiahDepartment of Medicine, School of Medicine, Faculty of Health Sciences, Nelson Mandela University, Gqeberha, South Africa.
Andrew D ReddLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Elizabeth van der MerweDepartment of Medicine, School of Medicine, Faculty of Health Sciences, Nelson Mandela University, Gqeberha, South Africa.

Funding

Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term OutcomesU01AI177211 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2023 to 2026
$6.9M
Maximizing the success of HIV+ to HIV+ kidney transplantation in South AfricaU01AI152153 · NIAID · UNIVERSITY OF CAPE TOWN · PI MULLER, ELMI · 2020 to 2024
$900k
NIAID NIH HHS U01 AI152153NIAID NIH HHS U01 AI177211
6 · The paper itself

Abstract

Introduction: Patients with chronic kidney disease (CKD) receiving dialysis (CKD-5D) are at increased risk for tuberculosis (TB), which significantly heightens the risk of mortality. Long-term isoniazid prevention therapy (IPT) to prevent TB is a promising strategy, although the safety and effectiveness of the approach in this high-risk population is unknown. Methods: Between 2019 and 2025, universal long-term IPT was administered to patients with CKD-5D ( Results: The incidence of TB (per 100,000 person-years [pys]) in the post-IPT cohort was 367, versus 4505 pre-IPT (92% relative risk reduction, Conclusion: Long-term IPT significantly reduced the incidence of TB in a high-risk cohort with CKD-5D. IPT was safe and well-tolerated, with < 10% of patients discontinuing therapy because of adverse events, which were generally mild and reversible. These findings provide strong real-world evidence supporting IPT use in TB-endemic dialysis populations.

Indexed as

chemoprophylaxisCKDdialysisisoniazid preventionsafetytuberculosis

Identifiers

PMID41550517
PMCPMC12805011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.