Evidence map›Paper›PMID 41550516›Full record

ArticleKidney international reports2026

Clonal Hematopoiesis and Kidney Function in the ASPREE Cohort.

Jasmine Singh, Kevan R Polkinghorne, Rory Wolfe, Nicholas C Wong, Sean Byars, Anna Leichter, Paul Lacaze, John J McNeil, Suzanne G Orchard, James Phung and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jasmine SinghSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Kevan R PolkinghorneSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Nicholas C WongAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Sean ByarsAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Anna LeichterAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
James PhungSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Hayley S RamshawMonash Antibody Discovery Platform and Robocore, Monash University, Melbourne, Victoria, Australia.
Le T P ThaoSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
James B WetmoreDivision of Nephrology, Department of Medicine, Hennepin Healthcare System, Minneapolis, Minnesota, USA.
Erica M WoodSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
David J CurtisAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Zoe K McQuiltenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) is emerging as a novel risk factor for many nonhematological diseases. Although some studies suggest that CHIP is associated with adverse kidney outcomes, the results are conflicting across cohorts. Methods: In this secondary analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) trial, we assessed the association between CHIP and kidney function in 9434 community-dwelling adults aged > 70 years. At baseline, participants were free of cardiovascular disease (CVD) and major life-limiting illness. In addition, we performed meta-analysis of published cohorts investigating the association between CHIP and incident kidney function decline. Results: Of the participants, 2124 of 9434 (22.5%) had CHIP, of whom 532 had variant allele fraction (VAF) ≥ 10% and 887 had a single non- Conclusion: We propose that the effect of CHIP is modified by participant factors, including comorbidities, partly accounting for heterogeneity across cohorts. This work contributes to a growing understanding of the interplay between CHIP and disease, and considerations in translating findings from large observational studies to individuals with CHIP.

Indexed as

agingASPREEclonal hematopoiesisinflammationkidneyurinary albumin

Identifiers

PMID41550516
PMCPMC12805017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.