ArticleBiochemistry and biophysics reports2026
Evaluation of myocardial microcirculation changes in rats from different altitudes based on CT myocardial perfusion imaging.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study employed computed tomography myocardial perfusion imaging (CT-MPI) to investigate myocardial microcirculation changes in rats across different altitudes. Four-week-old male Sprague-Dawley rats were allocated into plain (450 m), moderate-altitude (MA, 2200 m), and high-altitude (HA-A, 3800 m; HA-B, 4200 m) groups. After 28 weeks, CT-MPI revealed significant altitude-dependent alterations in myocardial perfusion parameters: TTP and MTT increased while BF and BV decreased (P < 0.05). Accompanying these changes were modifications in blood parameters-including red blood cell indices, white blood cell counts, and biochemical markers-along with myocardial structural remodeling characterized by disordered cell arrangement, widened intercellular gaps, and increased collagen deposition. Molecular analyses demonstrated variations in mRNA and protein expression of hypoxia-related markers (CD34, EPO, VEGF, HIF-1α, HIF-2α) and collagen types I/III, with HIF-2α exhibiting particular sensitivity to altitude variation. These findings indicate that high-altitude exposure induces progressive myocardial microcirculation impairment coupled with hematological adaptations and tissue remodeling, potentially mediated through HIF-2α-regulated hypoxia response pathways.
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