Evidence map›Paper›PMID 41550496›Full record

ArticleBiochemistry and biophysics reports2026

Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.

Therése Cedervall, Baptiste Jude, Ferdinand von Walden, Lilly Velentza, Johanna T Lanner, Thomas Sejersen, Farasat Zaman, Lars Sävendahl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Therése CedervallDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.
Baptiste JudeDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.
Ferdinand von WaldenDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.
Lilly VelentzaDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.
Johanna T LannerDept. of Physiology and Pharmacology, Karolinska Institutet, C3 Fysiologi och farmakologi, C3 FyFa Molekylär muskelfysiologi och patofysiologi, Stockholm, 171 77, Sweden.
Thomas SejersenDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.
Farasat ZamanDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.
Lars SävendahlDept. of Women's and Children's Health, Karolinska Institutet, K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, Stockholm, 171 77, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a progressive muscle disease for which glucocorticoid (GC) treatment is standard therapy. Patients typically suffer from short stature and osteoporosis, caused by the underlying disease and adverse effects of GCs. We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of DMD. Male mdx mice (B10.mdx and D2.mdx) were treated with GCs, with/without HNG, from 5 to 9 weeks of age using two different treatment regimens. Tibial growth was monitored by weekly X-ray imaging; growth plates analyzed with immunohistochemistry and histomorphometry; and bone structure examined using peripheral quantitative computed tomography. Effects on skeletal muscle were evaluated by immunohistochemistry, qPCR, and

Indexed as

Duchenne muscular dystrophyGlucocorticoidsGrowth retardationHumaninmdxOsteoporosis

Identifiers

PMID41550496
PMCPMC12811480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.