ArticleClinical case reports2026
ALK-Positive Histiocytosis With Unilateral Breast Involvement: A Case Report.
Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- ALK-Positive Histiocytosis With Unilateral Breast Involvement: A Case Report.Clinical case reports · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
APH is a rare disorder characterized by the proliferation of ALK-expressing histiocytes with variable anatomical involvement; however, mammary involvement is exceptionally rare. A 32-year-old woman presented with a painless right breast mass. Ultrasound identified a 9 × 8 mm hypoechoic nodule, categorized as BI-RADS 4A. Microscopy showed spindle cells in whorled patterns with characteristic nuclear folding. Immunohistochemistry demonstrated positivity for CD68, CD163, and ALK, and negativity for S-100, CD1a, and CD207. The Ki-67 proliferation index was approximately 10%. Fluorescence in situ hybridization (FISH) confirmed ALK gene rearrangement (The partner gene not identified), establishing the diagnosis of APH. The patient underwent complete resection without adjuvant therapy, and no recurrence was observed at the 15-month ultrasound follow-up. Accurate diagnosis of APH requires integration of histopathology, immunohistochemistry, and molecular testing to distinguish from other histiocytic disorders, with this case highlighting the rare presentation of APH in the breast.
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