Evidence map›Paper›PMID 41550296›Full record

ArticleTransplantation direct2026

Comparison of "Continuous" and "End-ischemic" Approaches of Oxygenated Hypothermic Machine Perfusion for Pancreas Preservation.

Mohamed Aly Mohamed Elshafei Elzawahry, John Fallon, Benoit Hastoy, Maria Letizia Lo Faro, Sameena Nawaz, Julien Branchereau, Anne Clark, Peter Friend, Rutger Ploeg, James Hunter

Abstract read
In one paragraph

Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed Aly Mohamed Elshafei ElzawahryNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-5300-912X
John FallonNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-8644-9380
Benoit HastoyOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-1244-7857
Maria Letizia Lo FaroNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-3846-0101
Sameena NawazOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-3894-4600
Julien BranchereauInstitut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.ORCID https://orcid.org/0000-0002-8460-9352
Anne ClarkOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-5007-3513
Peter FriendNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-0841-9685
Rutger PloegNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-7801-665X
James HunterNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-4972-6879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pancreas transplantation can successfully restore physiological insulin production, but it comes with a potentially significant morbidity burden. Pancreas grafts are extremely vulnerable to ischemia/reperfusion injury. Investigating technologies that aim to mitigate ischemia/reperfusion injury, such as oxygenated hypothermic machine perfusion (HMPO Methods: A circulatory death porcine model was used to compare different HMPO Results: The ischemic times and wet:dry ratios were comparable among the 3 groups. Perfusate flow increased throughout NR and was highest at the end of NR across all groups, with no significant difference between the groups. Amylase, lipase, lactate dehydrogenase, and cell-free DNA showed no significant differences in the pattern of change among the groups. Red blood cells were present consistently in vessels and islet capillaries at the end of NR in all pancreases. The continuous HMPO Conclusions: Continuous HMPO

Identifiers

PMID41550296
PMCPMC12806587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.