Evidence map›Paper›PMID 41550288›Full record

ArticleNational science review2026

Trace-stimuli-triggered controlled degradation for hydrogel adhesives.

Siming Li, Zilong Han, Weiqi Xu, Mingzhi Su, Yuchen Lu, Yao Shen, Yan Mu, Heng Zhu, Xiaohui Song, Panpan Ye and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siming LiZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.
Zilong HanZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.
Weiqi XuDepartment of Hepatic Surgery, Shanghai Cancer Center, Fudan University, Shanghai 200032, China.
Mingzhi SuZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.
Yuchen LuState Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.
Yao ShenZhejiang Key Laboratory of Clean Energy Conversion and Utilization, Science and Education Integration College of Energy and Carbon Neutralization, Zhejiang University of Technology, Hangzhou 310014, China.
Yan MuState Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.
Heng ZhuState Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.
Xiaohui SongZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.
Panpan YeZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.
Ke YaoZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.ORCID https://orcid.org/0000-0002-6764-7365
Wei YangState Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, and Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.
Shaoxing QuZhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou 310009, China.ORCID https://orcid.org/0000-0002-1217-4644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biodegradable hydrogels are promising for tissue adhesives and implantable coatings, but are often limited by harsh degradation triggers and uncontrolled breakdown. Here, we present a biodegradable hydrogel design strategy that leverages a redox-responsive crosslinker with a low activation threshold, enabling spatiotemporally controlled degradation in response to trace levels of reactive oxygen species (ROS). The hydrogel undergoes rapid and complete degradation, even under low redox stress, disassembling entirely within 2 h under 0.1% (w/w) ROS, and 24 h at concentrations as low as 0.0001% (w/w) (37°C). Functioning as a tissue adhesive, the hydrogel forms bonds within 5 s, maintains strong wet adhesion (200 J/m²), and exhibits excellent sealing performance in both

Indexed as

degradationhydrogellow activation thresholdtissue adhesives

Identifiers

PMID41550288
PMCPMC12805828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.