Evidence map›Paper›PMID 41550196›Full record

ArticleNagoya journal of medical science2025

Human dental pulp stem cells-derived small extracellular vesicles prevent osteoradionecrosis of the jaw in a rat model.

Go Ohara, Kazuto Okabe, Kotaro Sato, Naoto Toyama, Yuya Ohta, Kento Kaminogo, Junna Watanabe, Norihisa Ichimura, Kiyoshi Sakai, Hideharu Hibi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nagoya journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Go OharaDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuto OkabeDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kotaro SatoDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Naoto ToyamaDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuya OhtaDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kento KaminogoDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Japan.
Junna WatanabeDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Japan.
Norihisa IchimuraDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kiyoshi SakaiDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Japan.
Hideharu HibiDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy (RT) is an important standard treatment for head and neck cancer. On the other hand, osteoradionecrosis of the jaw (ORNJ), a side effect of RT, is intractable and has been a long-standing problem that needs to be overcome. Cellular senescence has been linked to the development of ORNJ; however, strategies for preventing and treating this disease have not been established. This study aimed to evaluate the effects of human dental pulp stem cell-derived small extracellular vesicles (hDPSC-sEV) on ORNJ. The effects of hDPSC-sEV treatment on rat bone marrow cells (rBMC) were examined in vitro. In addition, hDPSC-sEV were administered intravenously to a rat ORNJ model, and the extraction socket was examined radiologically and histologically. In vitro, rBMC treated with hDPSC-sEV immediately after irradiation showed downregulated expression of senescence-related genes. In vivo, the extraction sockets of the ORNJ models treated with hDPSC-sEV showed more new bone and greater coverage with gingiva relative to those observed in the comparison groups. This study suggests that hDPSC-sEV may inhibit ORNJ development. One possible mechanism is that hDPSC-sEV inhibit radiation-induced cellular senescence.

Indexed as

Dental PulpExtracellular VesiclesOsteoradionecrosisStem CellsAnimalsCellular SenescenceDisease Models, AnimalHumansMaleRatsRats, Sprague-Dawleycellular senescencedental pulp stem cellsextracellular vesicleosteoradionecrosis of the jawradiotherapy

Identifiers

PMID41550196
PMCPMC12805133

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.