ArticleComputational and structural biotechnology journal2026
Digital modeling of metformin and diet interactions on gut-microbiota metabolism in prediabetic patients.
Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Prediabetes confers a high risk of progressing to type 2 diabetes mellitus (T2DM). While metformin, a first-line T2DM therapy, improves glycemic control in prediabetes, its effects on the gut microbiota and host metabolic shifts remain poorly understood. Here, we applied a genome-scale community metabolic modeling to build a personalized "digital microbiota" for analyzing the metabolic activity of gut microbes in 106 samples of Mexican prediabetic patients, distributed among patients without treatment and patients treated with metformin over baseline, 6 and 12 months. To contrast microbial metabolic activity across groups and explore how diet modulates it, we simulated computationally the microbial metabolic fluxes under Western, Mediterranean, and traditional Milpa diets across the three groups. As expected, in general terms
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