Evidence map›Paper›PMID 41550085›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

Differential alpha-gal expression during

Tatenda Murangi, Ben Mans, Ronel Pienaar, Maresa Botha, Heidi Facey-Thomas, Stephen Cunningham, Ali Halajian, Lokesh Joshi, Franco H Falcone, William Horsnell and 1 more

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Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tatenda MurangiDivision of Immunology and Wellcome Centre for Infectious Diseases Research in Africa (CIDRI), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Ben MansEpidemiology, Parasites and Vectors, Agricultural Research Council-Onderstepoort Veterinary Research, Pretoria, South Africa.
Ronel PienaarEpidemiology, Parasites and Vectors, Agricultural Research Council-Onderstepoort Veterinary Research, Pretoria, South Africa.
Maresa BothaDivision of Paediatric Allergology, University of Cape Town, Cape Town, South Africa.
Heidi Facey-ThomasDivision of Paediatric Allergology, University of Cape Town, Cape Town, South Africa.
Stephen CunninghamAdvanced Glycoscience Research Cluster, University of Galway, Galway, Ireland.
Ali HalajianResearch Administration and Development, University of Limpopo, Sovenga, South Africa.
Lokesh JoshiAdvanced Glycoscience Research Cluster, University of Galway, Galway, Ireland.
Franco H FalconeInstitute of Parasitology, Biomedical Research Center Seltersberg (BFS), Justus Liebig University Giessen, Giessen, Germany.
William HorsnellDivision of Immunology and Wellcome Centre for Infectious Diseases Research in Africa (CIDRI), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Michael E LevinDivision of Paediatric Allergology, University of Cape Town, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The presence of galactose-α-1,3-galactose (alpha-gal) in tick salivary antigens has been implicated to initiate host IgE responses resulting in sensitization to alpha-gal. Objective: We sought to investigate the presence of alpha-gal in different anatomic locations in native South African tick species at different feeding and developmental stages and the ability of sera from our allergic cohort to bind to these tick proteins. Methods: Alpha-gal-containing proteins in laboratory-reared ticks at different feeding and developmental stages were detected through Western blotting and immunohistochemical staining. IgE and IgG4 toward the tick proteins were analyzed via ELISA. Results: There is differential expression of alpha-gal in endemic South African ticks Conclusions: We anticipate repeated exposure to differentially expressed

Indexed as

Alpha-galAmblyomma hebraeumfood allergygalactose-α-1,3-galactoseIgEred meat allergyRhipicephalus evertsiticks

Identifiers

PMID41550085
PMCPMC12811458

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.