Evidence map›Paper›PMID 41549969›Full record

ArticleBiomacromolecules2026

Lopinavir Derivative as Potent P-gp Inhibitor Enables Delivery through HPMA Copolymer Conjugates and Overcoming Tumor Chemoresistance to Conventional Cytostatic Drugs.

Daniil Starenko, Libor Kostka, Katerina Behalova, Lenka Kotrchova, Vladimir Subr, Jirina Kovarova, Radka Roubalova, Milada Sirova, Tomas Etrych, Marek Kovar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniil StarenkoInstitute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
Libor KostkaInstitute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.ORCID 0000-0002-7770-1855
Katerina BehalovaInstitute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
Lenka KotrchovaInstitute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.ORCID 0000-0003-4338-9362
Vladimir SubrInstitute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.
Jirina KovarovaInstitute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
Radka RoubalovaInstitute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
Milada SirovaInstitute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.ORCID 0000-0002-7645-1495
Tomas EtrychInstitute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.ORCID 0000-0001-5908-5182
Marek KovarInstitute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.ORCID 0000-0002-6602-1678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor chemoresistance caused by P-glycoprotein (P-gp) expression in cancer cells remains a significant challenge in cancer chemotherapy. Herein, a novel P-gp-inhibiting lopinavir derivative (LD) was synthesized via esterification of protease inhibitor lopinavir with 5-methyl-4-oxohexanoic acid. LD proved to be a potent P-gp inhibitor with EC

Indexed as

Antineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Cytostatic AgentsDrug Resistance, NeoplasmLopinavirMethacrylatesAnimalsCell Line, TumorDoxorubicinHumansMicePolymersAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Cytostatic AgentsDoxorubicinhydroxypropyl methacrylateLopinavirMethacrylatesPolymers

Identifiers

PMID41549969
PMCPMC12892249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.